Hsp90 inhibitor is a good candidate for effective combination therapy with carbon ions
نویسندگان
چکیده
Purpose/Background: To further improve the effectiveness of heavy ion radio-therapy, we studied the biology of a combined treatment using Hsp 90 inhibitor and carbon ion irradiation. We have previously reported that an Hsp90 inhibitor 17AAG can be an effective radio-sensitizer with X-rays for certain human tumor cells, while normal cells were not sensitized by this drug [1]. The underlying mechanism for this was demonstrated to be inhibition of DNA double-strand break (DSB) repair by 17AAG; particularly, homologous recombination repair (HRR) pathway was shown to be affected by this agent. In vivo mouse xenograft study also indicated a better tumor control with the combined treatment when compared with X-ray treatment alone.
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